The Dow Jones Industrial Average breached the 23,000-mark for the first time on Tuesday, powered by strong earnings from UnitedHealth and Johnson & Johnson.
The blue-chip index has surpassed four similar 1,000-point milestones this year, indicating investor faith in the bull-run despite lofty stock valuations.
The broader market, however, was weighed down by losses in industrial, financial and technology stocks.
Shares of the largest U.S. health insurer touched a life high, rising as much as 5.83 percent, after the company reported a stronger-than-expected profit and raised its full-year earnings forecast.
That, along with a 2.6 percent rise in Johnson & Johnson, led a 1 percent gain in the S&P healthcare sector.
Goldman Sachs dipped 2.07 percent despite reporting a profit beat and smaller-than-expected trading revenue fall. Morgan Stanley rose 0.92 percent as its wealth management business insulated the bank from weakness in trading revenue.
"There was some good earnings, real good economic data in spite of the hurricanes," said Peter Cardillo, chief market economist at First Standard Financial in New York.
"We're not seeing a market that's galloping along here. The market from a technical perspective is tired. What you're seeing is some hesitancy but not any major declines."
Treasury yields and dollar gained after a report that U.S. President Donald Trump was impressed by his meeting with economist John Taylor, who is considered to favor higher interest rates than current Federal Reserve Chair Janet Yellen.
The equity market, however, was not impacted by a report that Trump is likely to announce his choice before going to Asia in early November.
At 12:33 a.m. ET (1633 GMT), the S&P 500 was down 1.1 points, or 0.04 percent, at 2,556.54 and the Nasdaq Composite was down 2.98 points, or 0.05 percent, at 6,621.02.
The Dow Jones Industrial Average was up 19.47 points, or 0.08 percent, at 22,976.43, after briefly hitting the 23,000 mark, when only eight of its 30 components were making gains.
Nine of the 11 major S&P indexes were lower, led by a 0.42 percent drop in industrials index.
General Electric's 1.15 percent fall led losses in the industrial sector, while drop in shares of Microsoft and Intel weighed on the tech sector.
Netflix slipped 1.15 percent after touching a record high as more subscribers signed up for its popular original content in the latest quarter.